Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 11/20 | 1.00 |
| ▸ | NTRK3 | Q16288 | 3/20 | 1.00 |
| ▸ | TLK2 | Q86UE8 | 8/20 | 0.61 |
| ▸ | CDK1 | P06493 | 2/20 | 0.58 |
| ▸ | RET | P07949 | 2/20 | 0.58 |
| ▸ | CDK2 | P24941 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | KDR | P35968 | 2/20 | 0.58 |
| ▸ | GSK3A | P49840 | 2/20 | 0.58 |
| ▸ | GSK3B | P49841 | 2/20 | 0.58 |
| ▸ | CDK7 | P50613 | 2/20 | 0.58 |
| ▸ | CDK9 | P50750 | 2/20 | 0.58 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.58 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.58 |
| ▸ | PLK4 | O00444 | 1/20 | 0.58 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.58 |
| ▸ | AURKA | O14965 | 1/20 | 0.58 |
| ▸ | JAK2 | O60674 | 1/20 | 0.58 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.58 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29264960 | 1.00 | NTRK1 (1.00) | NTRK1NTRK3TLK2CDK1RET | |
| SCHEMBL29264957 | 0.89 | NTRK1 (1.00) | NTRK1NTRK3TLK2PDPK1 | |
| SCHEMBL29264955 | 0.89 | NTRK1 (1.00) | NTRK1NTRK3TLK2PDPK1 | |
| SCHEMBL30997321 | 0.88 | NTRK1 (0.79) | NTRK1NTRK3TLK2CDK1RET | |
| SCHEMBL29265015 | 0.88 | NTRK1 (0.79) | NTRK1NTRK3TLK2CDK1RET | |
| SCHEMBL29265020 | 0.88 | NTRK1 (0.79) | NTRK1NTRK3TLK2CDK1RET | |
| SCHEMBL29264983 | 0.86 | NTRK1 (1.00) | NTRK1NTRK3 | |
| SCHEMBL29264988 | 0.86 | NTRK1 (1.00) | NTRK1NTRK3 | |
| SCHEMBL29264971 | 0.82 | NTRK1 (1.00) | NTRK1NTRK3TLK2PDPK1 | |
| SCHEMBL29264975 | 0.82 | NTRK1 (1.00) | NTRK1NTRK3TLK2PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118221652-A | Indol-2-one derivative and preparation method and application thereof | 沈阳药科大学 | 2024-06-21 | — | — | CN | claimed |
| CN-118221652-A | Indol-2-one derivative and preparation method and application thereof | 沈阳药科大学 | 2024-06-21 | — | — | CN | disclosed |