Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 19/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.56 |
| ▸ | KIF5B | P33176 | 1/20 | 0.56 |
| ▸ | KDR | P35968 | 1/20 | 0.56 |
| ▸ | FLT3 | P36888 | 1/20 | 0.56 |
| ▸ | CCDC6 | Q16204 | 1/20 | 0.56 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ammonia Solution, Strong SCHEMBL29267484 | 0.99 | RET (0.55) | RETJAK2KIF5BKDRFLT3 | |
| SCHEMBL18789261 | 0.92 | RET (0.56) | RETJAK2KIF5BKDRFLT3 | |
| SCHEMBL29759472 | 0.91 | RET (0.55) | RETJAK2KIF5BKDRFLT3 | |
| Lithium Ion SCHEMBL29267480 | 0.90 | RET (0.54) | RETJAK2KIF5BKDRFLT3 | |
| SCHEMBL29598991 | 0.90 | RET (0.54) | RETJAK2KIF5BKDRFLT3 | |
| SCHEMBL26910157 | 0.90 | RET (0.54) | RETJAK2KIF5BKDRFLT3 | |
| SCHEMBL18789235 | 0.84 | RET (0.57) | RETJAK2KIF5BKDRFLT3 | |
| SCHEMBL22701692 | 0.83 | RET (0.42) | RETJAK2KIF5BKDRFLT3 | |
| SCHEMBL24668011 | 0.82 | AURKA (0.53) | JAK2 | |
| SCHEMBL18821778 | 0.82 | RET (0.47) | RETJAK2KIF5BKDRFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118056823-A | Preparation of key intermediate of platinib | 江苏慧聚药业股份有限公司 | 2024-05-21 | — | — | CN | claimed |
| CN-118056823-A | Preparation of key intermediate of platinib | 江苏慧聚药业股份有限公司 | 2024-05-21 | — | — | CN | disclosed |
| CN-118056823-A | Preparation of key intermediate of platinib | 江苏慧聚药业股份有限公司 | 2024-05-21 | — | — | CN | disclosed |
| EP-4255892-A1 | METHOD OF PREPARING PRALSETINIB | Blueprint Medicines Corporation (US) | 2023-10-11 | — | — | EP | disclosed |
| CN-116724024-A | Process for preparing platinib | 缆图药品公司 | 2023-09-08 | — | — | CN | disclosed |
| WO-2022120136-A1 | METHOD OF PREPARING PRALSETINIB | BLUEPRINT MEDICINES CORPORATION (US) | 2022-06-09 | — | — | WO | disclosed |