Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 7/20 | 0.62 |
| ▸ | BRAF | P15056 | 13/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.53 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.53 |
| ▸ | PLK4 | O00444 | 1/20 | 0.53 |
| ▸ | ACOX3 | O15254 | 1/20 | 0.53 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.53 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.53 |
| ▸ | JAK2 | O60674 | 1/20 | 0.53 |
| ▸ | ERN1 | O75460 | 1/20 | 0.53 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.53 |
| ▸ | STK10 | O94804 | 1/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.53 |
| ▸ | RAF1 | P04049 | 1/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.53 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | FYN | P06241 | 1/20 | 0.53 |
| ▸ | CDK1 | P06493 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2923736 | 0.88 | MAPK14 (0.64) | MAPK14BRAFKCNH2MAPK13RIPK1 | |
| SCHEMBL5058610 | 0.87 | MAPK14 (0.65) | MAPK14BRAFKCNH2MAPK13RIPK1 | |
| SCHEMBL5067797 | 0.87 | MAPK14 (0.61) | MAPK14BRAFKCNH2MAPK13RIPK1 | |
| SCHEMBL5062836 | 0.86 | MAPK14 (0.63) | MAPK14BRAFKCNH2MAPK13RIPK1 | |
| SCHEMBL1128969 | 0.86 | MAPK14 (0.69) | MAPK14BRAFKCNH2MAPK13RIPK1 | |
| SCHEMBL5058613 | 0.86 | MAPK14 (0.62) | MAPK14BRAFKCNH2MAPK13RIPK1 | |
| SCHEMBL2927715 | 0.86 | MAPK14 (0.63) | MAPK14BRAFKCNH2MAPK13RIPK1 | |
| SCHEMBL2923605 | 0.85 | MAPK14 (0.61) | MAPK14BRAFKCNH2MAPK13RIPK1 | |
| SCHEMBL5067783 | 0.85 | MAPK14 (0.62) | MAPK14BRAFMAPK13RIPK1PLK4 | |
| SCHEMBL3634875 | 0.85 | MAPK14 (0.68) | MAPK14BRAFMAPK13RIPK1PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2481736-A1 | Kinase inhibitors useful for the treatment of myleoproliferative diseases and other proliferative diseases | Deciphera Pharmaceuticals, LLC. (US) | 2012-08-01 | — | — | EP | disclosed |
| EP-2148677-A1 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF MYLEOPROLIFERATIVE DISEASES AND OTHER PROLIFERATIVE DISEASES | Deciphera Pharmaceuticals, LLC. (US) | 2010-02-03 | — | — | EP | disclosed |
| WO-2008131276-A1 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF MYLEOPROLIFERATIVE DISEASES AND OTHER PROLIFERATIVE DISEASES | DECIPHERA PHARMACEUTICALS, LLC (US) | 2008-10-30 | — | — | WO | disclosed |