SCHEMBL29275407

SCHEMBL29275407

Cc1ccc(NC(=O)c2cccnc2N2CCOCC2)cc1Nc1nc(-c2cccnc2)cs1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABL1 P00519 11/20 0.59
BCR P11274 10/20 0.59
PDGFRB P09619 3/20 0.59
KIT P10721 2/20 0.59
EGFR P00533 1/20 0.59
ERBB2 P04626 1/20 0.59
LCK P06239 1/20 0.59
FYN P06241 1/20 0.59
CSF1R P07333 1/20 0.59
YES1 P07947 1/20 0.59
LYN P07948 1/20 0.59
HCK P08631 1/20 0.59
FGR P09769 1/20 0.59
PIM1 P11309 1/20 0.59
SLC25A6 P12236 1/20 0.59
SRC P12931 1/20 0.59
BRAF P15056 1/20 0.59
NQO2 P16083 1/20 0.59
PDGFRA P16234 1/20 0.59
EPHA3 P29320 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30672541 1.00 ABL1 (0.59) ABL1BCRPDGFRBKITEGFR
SCHEMBL30672528 0.90 ABL1 (0.60) ABL1BCRPDGFRBKITEGFR
SCHEMBL29275419 0.90 ABL1 (0.60) ABL1BCRPDGFRBKITEGFR
SCHEMBL716387 0.85 ABL1 (0.63) ABL1BCRPDGFRBKITEGFR
SCHEMBL715940 0.81 ABL1 (0.85) ABL1BCRPDGFRBKITEGFR
SCHEMBL30672555 0.81 ABL1 (0.62) ABL1BCRPDGFRBKITEGFR
SCHEMBL717063 0.81 ABL1 (0.64) ABL1BCRPDGFRBKITEGFR
SCHEMBL717536 0.79 ABL1 (0.62) ABL1BCRPDGFRBKITEGFR
SCHEMBL4832888 0.79 ABL1 (0.79) ABL1BCRPDGFRBKITEGFR
SCHEMBL27632392 0.79 MEN1 (0.65) ABL1BCRPDGFRBKITEGFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117126153-A New coronavirus inhibitor, preparation method, pharmaceutical composition and application thereof 中国医学科学院药物研究所 2023-11-28 CN disclosed