Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 1/20 | 0.39 |
| ▸ | MAPKAPK2 | P49137 | 5/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.33 |
| ▸ | STK17B | O94768 | 1/20 | 0.32 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 2/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
| ▸ | METAP1 | P53582 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29277697 | 0.81 | ATR (0.49) | ATRMAPKAPK2GSK3BDYRK1ANPSR1 | |
| SCHEMBL7462692 | 0.80 | ATR (0.42) | ATRMAPKAPK2GSK3BDYRK1ANPSR1 | |
| SCHEMBL7455428 | 0.79 | ATR (0.41) | ATRMAPKAPK2GSK3BDYRK1ANPSR1 | |
| SCHEMBL29277701 | 0.78 | ATR (0.41) | ATRMAPKAPK2GSK3BDYRK1ANPSR1 | |
| SCHEMBL15402213 | 0.76 | MAPKAPK2 (0.47) | ATRMAPKAPK2 | |
| SCHEMBL29277699 | 0.74 | NPSR1 (0.41) | ATRDYRK1ANPSR1 | |
| SCHEMBL9897763 | 0.71 | ATR (0.39) | ATRMAPKAPK2GSK3BDYRK1ANPSR1 | |
| SCHEMBL32681564 | 0.70 | SYK (0.39) | ATRMAPKAPK2GSK3BDYRK1ANPSR1 | |
| SCHEMBL25138307 | 0.69 | ATR (0.42) | ATRACVR1BTGFBR1ACVRL1SYK | |
| SCHEMBL12233051 | 0.69 | MAPKAPK2 (0.44) | ATRMAPKAPK2GSK3BDYRK1ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117327053-A | Preparation method of PKC inhibitor darovasertib | 云南万宏医药科技有限公司 | 2024-01-02 | — | — | CN | disclosed |