Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27167804 | 0.83 | AAK1 (0.40) | GAAAAK1SIRT2SIRT1ALDH1A1 | |
| SCHEMBL16814170 | 0.83 | AAK1 (0.41) | GAAAAK1SIRT2SIRT1 | |
| SCHEMBL29279177 | 0.81 | PRMT5 (0.42) | GAAAAK1SIRT2SIRT1EPHX2 | |
| SCHEMBL16814171 | 0.81 | EPHX2 (0.41) | GAAAAK1EPHX2KDM1AMAOB | |
| SCHEMBL21179064 | 0.80 | GAA (0.44) | GAAAAK1SIRT2SIRT1EPHX2 | |
| SCHEMBL31704461 | 0.80 | GAA (0.44) | GAAAAK1SIRT2SIRT1EPHX2 | |
| SCHEMBL21178544 | 0.80 | GAA (0.44) | GAAAAK1SIRT2SIRT1EPHX2 | |
| SCHEMBL21178364 | 0.76 | TRPV1 (0.46) | GAAAAK1EPHX2BACE1NPC1 | |
| SCHEMBL8180722 | 0.76 | TRPV1 (0.46) | GAAAAK1EPHX2BACE1NPC1 | |
| SCHEMBL31055885 | 0.76 | TRPV1 (0.46) | GAAAAK1EPHX2BACE1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117580592-A | Compounds for targeting bruton's tyrosine kinase degradation | 渤健马萨诸塞州股份有限公司 | 2024-02-20 | — | — | CN | disclosed |