Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 2/20 | 0.54 |
| ▸ | PLAU | P00749 | 9/20 | 0.54 |
| ▸ | LSS | P48449 | 1/20 | 0.51 |
| ▸ | PLG | P00747 | 4/20 | 0.49 |
| ▸ | PLAT | P00750 | 4/20 | 0.49 |
| ▸ | KLKB1 | P03952 | 3/20 | 0.49 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.49 |
| ▸ | F2 | P00734 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.48 |
| ▸ | F10 | P00742 | 1/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2929377 | 0.93 | MCHR1 (0.60) | MCHR1LSSKLKB1MEN1KMT2A | |
| SCHEMBL2924753 | 0.84 | PLAU (0.52) | PLAUPLGPLATKLKB1PRSS1 | |
| SCHEMBL6308562 | 0.83 | MCHR1 (0.58) | MCHR1KLKB1MEN1KMT2ANPC1 | |
| SCHEMBL6305345 | 0.82 | MCHR1 (0.52) | MCHR1LSSKLKB1MEN1KMT2A | |
| SCHEMBL2928350 | 0.81 | MEN1 (0.55) | MCHR1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL2925645 | 0.80 | MCHR1 (0.55) | MCHR1KLKB1NPC1RAB9AF10 | |
| SCHEMBL5645754 | 0.80 | MCHR1 (0.68) | MCHR1KLKB1MEN1KMT2ANPC1 | |
| SCHEMBL13177428 | 0.78 | NPC1 (0.52) | MCHR1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL13885524 | 0.77 | KDM4E (0.67) | MEN1KMT2ANPC1RAB9AROCK2 | |
| SCHEMBL2925533 | 0.75 | MCHR1 (0.56) | MCHR1MEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1285651-B1 | MELANIN CONCENTRATING HORMONE ANTAGONISTS | TAKEDA PHARMACEUTICAL (JP) | 2010-09-01 | — | — | EP | disclosed |
| US-6930185-B2 | Melanin-concentrating hormone antagonist | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2005-08-16 | — | — | US | disclosed |
| US-20040077628-A1 | Melanin-concentrating hormone antagonist | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-04-22 | — | — | US | disclosed |
| EP-1285651-A1 | MELANIN CONCENTRATING HORMONE ANTAGONISTS | Takeda Chemical Industries, Ltd. (JP) | 2003-02-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040077628-A1 | Melanin-concentrating hormone antagonist | MCHR1, MC1R, MCHR2 | MCHR1 1/4885PLAU 3555/4885LSS 3656/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.