Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 7/20 | 0.42 |
| ▸ | HTR1A | P08908 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | PTPN2 | P17706 | 4/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.30 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.30 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.30 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.30 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.30 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.30 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2928559 | 0.88 | PTPN1 (0.37) | PTPN1HTR1AKCNH2HTR7SIGMAR1 | |
| SCHEMBL3213337 | 0.88 | PTPN1 (0.46) | PTPN1HTR1AKCNH2HTR7SIGMAR1 | |
| SCHEMBL2933699 | 0.84 | PTPN1 (0.48) | PTPN1HTR1AKCNH2HTR7SIGMAR1 | |
| SCHEMBL3214264 | 0.78 | PTPN1 (0.53) | PTPN1PTPN2 | |
| SCHEMBL2930264 | 0.76 | PTPN1 (0.48) | PTPN1PTPN2 | |
| SCHEMBL646019 | 0.76 | PTPN1 (0.53) | PTPN1PTPN2 | |
| SCHEMBL3202520 | 0.73 | PTPN1 (0.48) | PTPN1HTR7PTPN2 | |
| SCHEMBL2929970 | 0.73 | PTPN1 (0.47) | PTPN1SIGMAR1PTPN2 | |
| SCHEMBL3224718 | 0.73 | PTPN1 (0.49) | PTPN1PTPN2 | |
| SCHEMBL3225865 | 0.73 | PTPN1 (0.53) | PTPN1PTPN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2227245-A2 | COMBINATION OF PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND HUMAN GROWTH HORMONE FOR THE TREATMENT OF MUSCLE ATROPHY AND RELATED DISORDERS | Novartis AG (CH) | 2010-09-15 | — | — | EP | disclosed |
| WO-2009068689-A2 | COMBINATION OF PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND HUMAN GROWTH HORMONE FOR THE TREATMENT OF MUSCLE ATROPHY AND RELATED DISORDERS | NOVARTIS AG (CH) | 2009-06-04 | — | — | WO | disclosed |