Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 20/20 | 0.69 |
| ▸ | SRC | P12931 | 4/20 | 0.52 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.52 |
| ▸ | HCK | P08631 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2926335 | 0.89 | BRAF (0.68) | BRAFSRCMAPK12MAPK14 | |
| SCHEMBL3762215 | 0.89 | BRAF (0.65) | BRAFSRCMAPK12MAPK14HCK | |
| SCHEMBL2931602 | 0.86 | BRAF (0.73) | BRAFSRCMAPK12MAPK14 | |
| SCHEMBL2928589 | 0.84 | BRAF (0.68) | BRAFSRCMAPK12MAPK14HCK | |
| SCHEMBL13822038 | 0.84 | BRAF (0.57) | BRAFSRCMAPK12MAPK14HCK | |
| SCHEMBL2931611 | 0.83 | BRAF (0.66) | BRAFSRCMAPK12MAPK14HCK | |
| SCHEMBL3054691 | 0.83 | BRAF (1.00) | BRAFSRCMAPK12MAPK14HCK | |
| SCHEMBL2934109 | 0.82 | BRAF (1.00) | BRAF | |
| SCHEMBL13822067 | 0.82 | BRAF (0.78) | BRAFSRCMAPK12MAPK14HCK | |
| SCHEMBL2931944 | 0.82 | BRAF (0.54) | BRAFSRCMAPK12MAPK14HCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229391-A1 | PYRIDO[2,3-B]PYRAZINE-8-SUBSTITUTED COMPOUNDS AND THEIR USE | Cancer Research Technology Limited (GB) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009077766-A1 | PYRIDO[2,3-B]PYRAZINE-8-SUBSTITUTED COMPOUNDS AND THEIR USE | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2009-06-25 | — | — | WO | disclosed |