Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.62 |
| ▸ | RAB9A | P51151 | 2/20 | 0.62 |
| ▸ | CNR2 | P34972 | 4/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24364908 | 0.95 | NPC1 (0.68) | NPC1RAB9ACNR2CNR1IDO1 | |
| SCHEMBL31145141 | 0.95 | NPC1 (0.68) | NPC1RAB9ACNR2CNR1IDO1 | |
| SCHEMBL12209530 | 0.78 | NPC1 (0.97) | NPC1RAB9AIDO1SMN1; SMN2NPSR1 | |
| SCHEMBL30551597 | 0.77 | NPC1 (0.94) | NPC1RAB9AIDO1SMN1; SMN2NPSR1 | |
| SCHEMBL24367508 | 0.76 | NPC1 (0.58) | NPC1RAB9ACNR2CNR1SMN1; SMN2 | |
| SCHEMBL32688935 | 0.76 | NPC1 (0.58) | NPC1RAB9ACNR2CNR1SMN1; SMN2 | |
| SCHEMBL30753156 | 0.76 | NPC1 (0.65) | NPC1RAB9AIDO1SMN1; SMN2NPSR1 | |
| SCHEMBL24365278 | 0.75 | NPC1 (0.64) | NPC1RAB9ACNR2CNR1IDO1 | |
| SCHEMBL31145058 | 0.75 | NPC1 (0.64) | NPC1RAB9ACNR2CNR1IDO1 | |
| SCHEMBL24365159 | 0.75 | NPC1 (0.72) | NPC1RAB9AIDO1SMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3735411-B1 | 1,3,4,5-TETRAHYDRO-2H-PYRIDO[4,3-B]INDOLE DERIVATIVES FOR THE TREATMENT, ALLEVIATION OR PREVENTION OF DISORDERS ASSOCIATED WITH TAU AGGREGATES LIKE ALZHEIMER`S DISEASE | AC IMMUNE SA (CH) | 2024-07-10 | — | — | EP | disclosed |