Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLA1 | P09884 | 6/20 | 0.63 |
| ▸ | NR1H2 | P55055 | 9/20 | 0.60 |
| ▸ | NR1H3 | Q13133 | 9/20 | 0.60 |
| ▸ | SOD1 | P00441 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | ABHD16A | O95870 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20561208 | 1.00 | POLA1 (0.63) | POLA1NR1H2NR1H3SOD1CYP3A4 | |
| SCHEMBL20561209 | 1.00 | POLA1 (0.63) | POLA1NR1H2NR1H3SOD1CYP3A4 | |
| SCHEMBL20561235 | 0.93 | NR1H2 (0.70) | POLA1NR1H2NR1H3SOD1CYP3A4 | |
| SCHEMBL31678855 | 0.93 | NR1H2 (0.70) | POLA1NR1H2NR1H3SOD1CYP3A4 | |
| SCHEMBL20560979 | 0.91 | POLA1 (0.73) | POLA1NR1H2NR1H3CYP3A4CYP2C9 | |
| SCHEMBL29295275 | 0.86 | POLA1 (0.62) | POLA1NR1H2NR1H3SOD1CYP3A4 | |
| SCHEMBL24177920 | 0.85 | POLA1 (0.81) | POLA1NR1H2NR1H3SOD1CYP3A4 | |
| SCHEMBL12292033 | 0.85 | POLA1 (0.81) | POLA1NR1H2NR1H3SOD1CYP3A4 | |
| SCHEMBL19770990 | 0.85 | POLA1 (0.81) | POLA1NR1H2NR1H3SOD1CYP3A4 | |
| SCHEMBL19786219 | 0.85 | POLA1 (0.81) | POLA1NR1H2NR1H3SOD1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3883926-B1 | BIS-OCTAHYDROPHENANTHRENE CARBOXAMIDE DERIVATIVES AND PROTEIN CONJUGATES THEREOF FOR USE AS LXR AGONISTS | REGENERON PHARMA (US) | 2024-07-10 | — | — | EP | disclosed |