Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLA1 | P09884 | 4/20 | 0.72 |
| ▸ | NR1H2 | P55055 | 8/20 | 0.66 |
| ▸ | NR1H3 | Q13133 | 8/20 | 0.66 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.59 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.55 |
| ▸ | KARS1 | Q15046 | 2/20 | 0.53 |
| ▸ | RXRA | P19793 | 1/20 | 0.53 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.53 |
| ▸ | CDK2 | P24941 | 1/20 | 0.53 |
| ▸ | RXRB | P28702 | 1/20 | 0.53 |
| ▸ | RXRG | P48443 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | APEX1 | P27695 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6312190 | 1.00 | POLA1 (0.72) | POLA1NR1H2NR1H3PTPN1PDE4D | |
| SCHEMBL6309929 | 1.00 | POLA1 (0.72) | POLA1NR1H2NR1H3PTPN1PDE4D | |
| SCHEMBL20561120 | 1.00 | POLA1 (0.72) | POLA1NR1H2NR1H3PTPN1PDE4D | |
| SCHEMBL6309935 | 1.00 | POLA1 (0.72) | POLA1NR1H2NR1H3PTPN1PDE4D | |
| SCHEMBL6312187 | 1.00 | POLA1 (0.72) | POLA1NR1H2NR1H3PTPN1PDE4D | |
| SCHEMBL6309781 | 0.92 | NR1H2 (0.69) | POLA1NR1H2NR1H3PTPN1CYP2C9 | |
| SCHEMBL6312196 | 0.92 | NR1H2 (0.64) | POLA1NR1H2NR1H3PTPN1CYP2C9 | |
| SCHEMBL20561720 | 0.92 | NR1H2 (0.64) | POLA1NR1H2NR1H3PTPN1CYP2C9 | |
| SCHEMBL31678856 | 0.92 | NR1H2 (0.64) | POLA1NR1H2NR1H3PTPN1CYP2C9 | |
| SCHEMBL6309780 | 0.92 | NR1H2 (0.69) | POLA1NR1H2NR1H3PTPN1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3883926-B1 | BIS-OCTAHYDROPHENANTHRENE CARBOXAMIDE DERIVATIVES AND PROTEIN CONJUGATES THEREOF FOR USE AS LXR AGONISTS | REGENERON PHARMA (US) | 2024-07-10 | — | — | EP | disclosed |