Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 16/20 | 0.39 |
| ▸ | BACE2 | Q9Y5Z0 | 13/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2929943 | 1.00 | BACE1 (0.39) | BACE1BACE2KCNH2 | |
| SCHEMBL3773683 | 0.92 | BACE1 (0.46) | BACE1BACE2KCNH2 | |
| SCHEMBL2619967 | 0.87 | BACE1 (0.38) | BACE1BACE2KCNH2 | |
| SCHEMBL16966343 | 0.87 | BACE1 (0.46) | BACE1BACE2KCNH2 | |
| SCHEMBL3774893 | 0.87 | BACE1 (0.46) | BACE1BACE2KCNH2 | |
| SCHEMBL2932708 | 0.84 | BACE1 (0.42) | BACE1BACE2KCNH2 | |
| SCHEMBL2932704 | 0.84 | BACE1 (0.42) | BACE1BACE2KCNH2 | |
| SCHEMBL2932020 | 0.81 | BACE1 (0.41) | BACE1BACE2KCNH2 | |
| SCHEMBL15818093 | 0.81 | BACE1 (0.39) | BACE1BACE2KCNH2 | |
| SCHEMBL2932512 | 0.80 | BACE1 (0.45) | BACE1BACE2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2233474-B1 | CONDENSED AMINODIHYDROTHIAZINE DERIVATIVE | EISAI R&D MAN CO LTD (JP) | 2015-08-05 | — | — | EP | disclosed |
| EP-2233474-A1 | CONDENSED AMINODIHYDROTHIAZINE DERIVATIVE | Eisai R&D Management Co., Ltd. (JP) | 2010-09-29 | — | — | EP | disclosed |