Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 10/20 | 0.38 |
| ▸ | BRAF | P15056 | 4/20 | 0.37 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.36 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29879450 | 1.00 | TYK2 (0.38) | TYK2BRAFTRPM5ACVRL1 | |
| SCHEMBL24738018 | 1.00 | TYK2 (0.38) | TYK2BRAFTRPM5ACVRL1 | |
| SCHEMBL29879221 | 0.94 | TYK2 (0.37) | TYK2BRAF | |
| SCHEMBL24737785 | 0.94 | TYK2 (0.37) | TYK2BRAF | |
| SCHEMBL29302935 | 0.94 | TYK2 (0.40) | TYK2BRAFTRPM5 | |
| SCHEMBL24738337 | 0.94 | TYK2 (0.38) | TYK2BRAF | |
| SCHEMBL29136842 | 0.94 | TYK2 (0.38) | TYK2BRAF | |
| SCHEMBL29136843 | 0.94 | TYK2 (0.38) | TYK2BRAF | |
| SCHEMBL29302934 | 0.93 | TYK2 (0.37) | TYK2BRAFTRPM5ACVRL1 | |
| SCHEMBL29879383 | 0.93 | TYK2 (0.37) | TYK2BRAFTRPM5ACVRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240228488-A1 | HETEROARYL INHIBITORS OF PLASMA KALLIKREIN | TAKEDA PHARMACEUTICALS CO (JP) | 2024-07-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240228488-A1 | HETEROARYL INHIBITORS OF PLASMA KALLIKREIN | KLKB1, KLK5, KLK1 | TYK2 1836/4885BRAF 3329/4885TRPM5 3866/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.