Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 4/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CA7 | P43166 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2930584 | 0.85 | PTGER4 (0.52) | PTGER4CYP1A2CYP2D6 | |
| SCHEMBL2926785 | 0.85 | PTGER4 (0.55) | PTGER4CYP1A2CYP2D6 | |
| SCHEMBL10079622 | 0.83 | PTGER4 (0.37) | PTGER4CYP1A2CYP2D6 | |
| SCHEMBL13177685 | 0.81 | PTGER4 (0.47) | PTGER4CYP1A2CYP2D6 | |
| SCHEMBL10078896 | 0.80 | PTGER4 (0.40) | PTGER4CYP1A2CYP2D6 | |
| SCHEMBL13594947 | 0.78 | PTGER4 (0.47) | PTGER4CYP1A2CYP2D6 | |
| SCHEMBL10078418 | 0.76 | PTGER4 (0.37) | PTGER4CYP1A2CYP2D6CA1CA2 | |
| SCHEMBL10078916 | 0.76 | PTGER4 (0.46) | PTGER4CYP1A2CYP2D6 | |
| SCHEMBL13594923 | 0.76 | PTGER4 (0.48) | PTGER4CYP1A2CYP2D6MAPT | |
| SCHEMBL13594930 | 0.75 | PTGER4 (0.48) | PTGER4CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081897-B1 | ISOINDOL DERIVATIVES AS EP4 RECEPTOR AGONISTS | GLAXO GROUP LTD (GB) | 2010-09-15 | — | — | EP | disclosed |