Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 18/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.70 |
| ▸ | BACE2 | Q9Y5Z0 | 5/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.58 |
| ▸ | CTSD | P07339 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2930859 | 1.00 | BACE1 (0.70) | BACE1KCNH2BACE2CYP2D6CTSD | |
| SCHEMBL8030166 | 1.00 | BACE1 (0.70) | BACE1KCNH2BACE2CYP2D6CTSD | |
| SCHEMBL2620271 | 1.00 | BACE1 (0.70) | BACE1KCNH2BACE2CYP2D6CTSD | |
| SCHEMBL15165562 | 0.92 | BACE1 (0.72) | BACE1KCNH2BACE2CYP2D6CTSD | |
| SCHEMBL2966127 | 0.92 | BACE1 (0.72) | BACE1KCNH2BACE2CYP2D6CTSD | |
| SCHEMBL2620180 | 0.92 | BACE1 (0.72) | BACE1KCNH2BACE2CYP2D6CTSD | |
| SCHEMBL2620265 | 0.90 | BACE1 (0.68) | BACE1KCNH2BACE2CYP2D6 | |
| SCHEMBL2931905 | 0.90 | BACE1 (0.68) | BACE1KCNH2BACE2CYP2D6 | |
| SCHEMBL2620267 | 0.90 | BACE1 (0.68) | BACE1KCNH2BACE2CYP2D6 | |
| SCHEMBL2620272 | 0.90 | BACE1 (0.74) | BACE1KCNH2BACE2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2233474-A1 | CONDENSED AMINODIHYDROTHIAZINE DERIVATIVE | Eisai R&D Management Co., Ltd. (JP) | 2010-09-29 | — | — | EP | disclosed |