Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 11/20 | 0.69 |
| ▸ | MAP3K7 | O43318 | 5/20 | 0.69 |
| ▸ | IRAK1 | P51617 | 3/20 | 0.69 |
| ▸ | ALK | Q9UM73 | 8/20 | 0.63 |
| ▸ | MET | P08581 | 2/20 | 0.63 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29313515 | 1.00 | IRAK4 (0.69) | IRAK4MAP3K7IRAK1ALKMET | |
| SCHEMBL29313630 | 0.94 | IRAK4 (0.65) | IRAK4MAP3K7IRAK1ALKMET | |
| SCHEMBL29313509 | 0.93 | IRAK4 (0.59) | IRAK4MAP3K7IRAK1ALKMET | |
| SCHEMBL20985417 | 0.88 | IRAK4 (0.88) | IRAK4MAP3K7IRAK1ALKMET | |
| SCHEMBL21025642 | 0.88 | IRAK4 (0.88) | IRAK4MAP3K7IRAK1ALKMET | |
| SCHEMBL20985418 | 0.88 | IRAK4 (0.88) | IRAK4MAP3K7IRAK1ALKMET | |
| SCHEMBL29313616 | 0.87 | IRAK4 (0.64) | IRAK4MAP3K7IRAK1ALKMET | |
| SCHEMBL29313643 | 0.87 | IRAK4 (0.61) | IRAK4MAP3K7IRAK1ALKMET | |
| SCHEMBL29313511 | 0.86 | IRAK4 (0.68) | IRAK4MAP3K7IRAK1ALKMET | |
| SCHEMBL29313639 | 0.85 | IRAK4 (0.59) | IRAK4MAP3K7IRAK1ALKMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12036209-B2 | Compounds and methods for the targeted degradation of Interleukin-1 receptor-associated kinase 4 polypeptides | ARVINAS OPERATIONS, INC. (US) | 2024-07-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12036209-B2 | Compounds and methods for the targeted degradation of Interleukin-1 receptor-associated kinase 4 polypeptides | IRAK1, IRAK4, IRAK2 | IRAK4 2/4885MAP3K7 533/4885IRAK1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.