Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 7/20 | 0.86 |
| ▸ | IRAK4 | Q9NWZ3 | 7/20 | 0.86 |
| ▸ | IRAK1 | P51617 | 6/20 | 0.86 |
| ▸ | EGFR | P00533 | 12/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29313976 | 0.93 | MAP3K7 (0.85) | MAP3K7IRAK4IRAK1EGFR | |
| SCHEMBL29313973 | 0.93 | IRAK4 (0.74) | MAP3K7IRAK4IRAK1EGFR | |
| SCHEMBL1924466 | 0.93 | MAP3K7 (1.00) | MAP3K7IRAK4IRAK1EGFR | |
| SCHEMBL1924016 | 0.91 | IRAK4 (1.00) | MAP3K7IRAK4IRAK1EGFR | |
| SCHEMBL1923717 | 0.90 | MAP3K7 (0.88) | MAP3K7IRAK4IRAK1EGFR | |
| SCHEMBL1924565 | 0.89 | MAP3K7 (0.86) | MAP3K7IRAK4IRAK1EGFR | |
| SCHEMBL21025881 | 0.88 | IRAK4 (0.82) | MAP3K7IRAK4IRAK1EGFR | |
| SCHEMBL29313956 | 0.86 | IRAK4 (0.85) | MAP3K7IRAK4IRAK1EGFR | |
| SCHEMBL1924193 | 0.86 | MAP3K7 (0.82) | MAP3K7IRAK4IRAK1EGFR | |
| SCHEMBL29313978 | 0.86 | MAP3K7 (0.73) | MAP3K7IRAK4IRAK1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12036209-B2 | Compounds and methods for the targeted degradation of Interleukin-1 receptor-associated kinase 4 polypeptides | ARVINAS OPERATIONS, INC. (US) | 2024-07-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12036209-B2 | Compounds and methods for the targeted degradation of Interleukin-1 receptor-associated kinase 4 polypeptides | IRAK1, IRAK4, IRAK2 | MAP3K7 533/4885IRAK4 2/4885IRAK1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.