Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.85 |
| ▸ | CHEK2 | O96017 | 5/20 | 0.61 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.61 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.56 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.52 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | RAF1 | P04049 | 1/20 | 0.49 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.48 |
| ▸ | MTOR | P42345 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2931563 | 0.87 | POLB (0.69) | POLBCHEK2PIK3CAAKR1C3HSP90AA1 | |
| SCHEMBL2929209 | 0.84 | POLB (0.68) | POLBCHEK2PIK3CAAKR1C3HSP90AA1 | |
| SCHEMBL2929913 | 0.84 | POLB (0.68) | POLBCHEK2PIK3CAAKR1C3HSP90AA1 | |
| SCHEMBL2931459 | 0.82 | POLB (0.65) | POLBCHEK2PIK3CAAKR1C3HSP90AA1 | |
| SCHEMBL2930881 | 0.82 | POLB (0.62) | POLBCHEK2PIK3CAAKR1C3HSP90AA1 | |
| SCHEMBL4166869 | 0.81 | POLB (0.61) | POLBCHEK2PIK3CAAKR1C3RAF1 | |
| SCHEMBL1965467 | 0.81 | POLB (0.60) | POLBCHEK2PIK3CAAKR1C3HSP90AA1 | |
| SCHEMBL2929926 | 0.79 | AKR1C3 (0.66) | POLBCHEK2PIK3CAAKR1C3HSP90AA1 | |
| SCHEMBL3767781 | 0.78 | AKR1C3 (0.73) | POLBAKR1C3NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL20819207 | 0.77 | HSP90AA1 (0.60) | POLBCHEK2PIK3CAAKR1C3HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7820821-B2 | Benzazole derivatives, compositions, and methods of use as aurora kinase inhibitors | TRANSTECH PHARMA, INC. (US) | 2010-10-26 | — | — | US | disclosed |
| US-20100152170-A1 | Benzazole Derivatives, Compositions, And Methods Of Use As Aurora Kinase Inhibitors | TRANSTECH PHARMA, INC. (US) | 2010-06-17 | — | — | US | disclosed |
| US-20070219235-A1 | Benzazole derivatives, compositions, and methods of use as aurora kinase inhibitors | VTVX HOLDINGS I LLC | 2007-09-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100152170-A1 | Benzazole Derivatives, Compositions, And Methods Of Use As Aurora Kinase Inhibitors | AURKC, AURKA, AURKB | POLB 1990/4885CHEK2 14/4885PIK3CA 21/4885 |
| US-20070219235-A1 | Benzazole derivatives, compositions, and methods of use as aurora kinase inhibitors | AURKC, AURKA, AURKB | POLB 1990/4885CHEK2 14/4885PIK3CA 21/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.