Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 16/20 | 0.45 |
| ▸ | NAMPT | P43490 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2931640 | 1.00 | HRH3 (0.45) | HRH3NAMPTALDH1A1 | |
| SCHEMBL2927075 | 0.81 | NAMPT (0.46) | HRH3NAMPTALDH1A1 | |
| SCHEMBL2924457 | 0.81 | HRH3 (0.52) | HRH3NAMPT | |
| SCHEMBL2927073 | 0.81 | NAMPT (0.46) | HRH3NAMPTALDH1A1 | |
| SCHEMBL2924458 | 0.81 | HRH3 (0.52) | HRH3NAMPT | |
| SCHEMBL2924869 | 0.80 | HRH3 (0.51) | HRH3NAMPTALDH1A1 | |
| SCHEMBL2924865 | 0.80 | HRH3 (0.51) | HRH3NAMPTALDH1A1 | |
| SCHEMBL2929879 | 0.79 | HRH3 (0.48) | HRH3ALDH1A1 | |
| SCHEMBL2929881 | 0.79 | HRH3 (0.48) | HRH3ALDH1A1 | |
| SCHEMBL2924911 | 0.78 | DPP4 (0.51) | HRH3NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2158189-B1 | CYCLOHEXYL DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2010-09-15 | — | — | EP | claimed |
| US-7544683-B2 | Cyclohexyl derivatives | HOFFMANN-LA ROCHE INC. (US) | 2009-06-09 | — | — | US | claimed |
| US-20090005380-A1 | CYCLOHEXYL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-01-01 | — | — | US | claimed |
| EP-2158189-B1 | CYCLOHEXYL DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2010-09-15 | — | — | EP | disclosed |
| EP-2158189-A1 | CYCLOHEXYL DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2010-03-03 | — | — | EP | disclosed |
| US-7544683-B2 | Cyclohexyl derivatives | HOFFMANN-LA ROCHE INC. (US) | 2009-06-09 | — | — | US | disclosed |
| WO-2008151957-A9 | CYCLOHEXYL DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2009-03-05 | — | — | WO | disclosed |
| US-20090005380-A1 | CYCLOHEXYL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-01-01 | — | — | US | disclosed |
| WO-2008151957-A1 | CYCLOHEXYL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-12-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090005380-A1 | CYCLOHEXYL DERIVATIVES | HRH3, HRH4, HCAR2 | HRH3 1/4885NAMPT 2220/4885ALDH1A1 344/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.