Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26741504 | 1.00 | CHRM5 (0.42) | CHRM5CHRM3HTTSIGMAR1ALDH1A1 | |
| SCHEMBL26744000 | 1.00 | CHRM5 (0.42) | CHRM5CHRM3HTTSIGMAR1ALDH1A1 | |
| SCHEMBL26744127 | 0.96 | CHRM5 (0.41) | CHRM5CHRM3HTTSIGMAR1ALDH1A1 | |
| SCHEMBL26741500 | 0.96 | CHRM5 (0.41) | CHRM5CHRM3HTTSIGMAR1ALDH1A1 | |
| SCHEMBL26744128 | 0.96 | CHRM5 (0.41) | CHRM5CHRM3HTTSIGMAR1ALDH1A1 | |
| SCHEMBL26750619 | 0.94 | HTT (0.45) | CHRM5CHRM3HTTSIGMAR1ALDH1A1 | |
| SCHEMBL29316594 | 0.94 | HTT (0.45) | CHRM5CHRM3HTTSIGMAR1ALDH1A1 | |
| SCHEMBL26743067 | 0.94 | HTT (0.45) | CHRM5CHRM3HTTSIGMAR1ALDH1A1 | |
| SCHEMBL26744140 | 0.93 | CHRM5 (0.43) | CHRM5CHRM3HTTSIGMAR1ALDH1A1 | |
| SCHEMBL26744142 | 0.93 | CHRM5 (0.43) | CHRM5CHRM3HTTSIGMAR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240238423-A9 | TETRAHYDROISOQUINOLINE HETEROBIFUNCTIONAL BCL-XL DEGRADERS | Treeline Biosciences, Inc. | 2024-07-18 | — | — | US | disclosed |
| US-20240238423-A9 | TETRAHYDROISOQUINOLINE HETEROBIFUNCTIONAL BCL-XL DEGRADERS | Treeline Biosciences, Inc. | 2024-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240238423-A9 | TETRAHYDROISOQUINOLINE HETEROBIFUNCTIONAL BCL-XL DEGRADERS | BCL2A1, BCL2L1, BCL3 | CHRM5 4872/4885CHRM3 4860/4885HTT 889/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.