Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMIGD3 | P0DMS9 | 2/20 | 0.54 |
| ▸ | HTR2C | P28335 | 2/20 | 0.54 |
| ▸ | HTR2B | P41595 | 2/20 | 0.54 |
| ▸ | PDE2A | O00408 | 1/20 | 0.49 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.47 |
| ▸ | YTHDF3 | Q7Z739 | 2/20 | 0.46 |
| ▸ | YTHDC1 | Q96MU7 | 2/20 | 0.46 |
| ▸ | YTHDF1 | Q9BYJ9 | 2/20 | 0.46 |
| ▸ | YTHDF2 | Q9Y5A9 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.45 |
| ▸ | HTR3A | P46098 | 1/20 | 0.45 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | PPARD | Q03181 | 5/20 | 0.44 |
| ▸ | PDE5A | O76074 | 1/20 | 0.44 |
| ▸ | CDC7 | O00311 | 1/20 | 0.44 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20333337 | 0.87 | APP (0.54) | KMT2AAPPPDE5A | |
| SCHEMBL19459471 | 0.73 | TMIGD3 (0.68) | TMIGD3HTR2CHTR2BPDE2AGRM4 | |
| SCHEMBL30141144 | 0.73 | TMIGD3 (0.68) | TMIGD3HTR2CHTR2BPDE2AGRM4 | |
| SCHEMBL11899898 | 0.72 | APP (0.58) | TMIGD3HTR2CHTR2BPDE2AKMT2A | |
| SCHEMBL22866364 | 0.69 | PDE2A (0.56) | TMIGD3HTR2CHTR2BPDE2AGRM4 | |
| SCHEMBL18895144 | 0.68 | BRD4 (0.61) | TMIGD3HTR2CHTR2BPDE2AKMT2A | |
| SCHEMBL20539622 | 0.68 | APP (0.56) | TMIGD3HTR2CHTR2BPDE2AKMT2A | |
| SCHEMBL30208466 | 0.68 | APP (0.56) | TMIGD3HTR2CHTR2BPDE2AKMT2A | |
| SCHEMBL6700054 | 0.66 | CHRM2 (0.55) | KMT2AAPP | |
| SCHEMBL632217 | 0.66 | CHRM2 (0.55) | KMT2AAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3445368-B1 | COMPOUNDS AND METHODS FOR TREATING NEUROLOGICAL AND CARDIOVASCULAR CONDITIONS | ASTROCYTE PHARMACEUTICALS INC (US) | 2024-07-17 | — | — | EP | disclosed |