⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16781667 | 0.77 | — | — | |
| SCHEMBL1180586 | 0.75 | — | — | |
| SCHEMBL12287341 | 0.75 | — | — | |
| SCHEMBL29845509 | 0.75 | — | — | |
| SCHEMBL19936157 | 0.75 | — | — | |
| SCHEMBL24404928 | 0.75 | — | — | |
| SCHEMBL663225 | 0.75 | — | — | |
| SCHEMBL29393124 | 0.75 | — | — | |
| SCHEMBL3585029 | 0.73 | — | — | |
| SCHEMBL584147 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240391900-A1 | RIP1 KINASE INHIBITOR AND USE THEREOF | SIRONAX (BEIJING) CO., LTD. (CN) | 2024-11-28 | — | — | US | disclosed |
| EP-4400497-A1 | 3CLPRO PROTEASE INHIBITOR | Shanghai Qilu Pharmaceutical Research and Development Centre Ltd. (CN) | 2024-07-17 | — | — | EP | disclosed |
| CN-117957230-A | RIP1 kinase inhibitors and uses thereof | 维泰瑞隆（北京）生物科技有限公司 | 2024-04-30 | — | — | CN | disclosed |
| WO-2023040870-A1 | RIP1 KINASE INHIBITOR AND USE THEREOF | 维泰瑞隆（北京）生物科技有限公司 | 2023-03-23 | — | — | WO | disclosed |
| WO-2023039795-A1 | RIP1 KINASE INHIBITOR AND USE THEREOF | 维泰瑞隆（北京）生物科技有限公司 | 2023-03-23 | — | — | WO | disclosed |