Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSA | P10619 | 2/20 | 0.46 |
| ▸ | PSMB5 | P28074 | 3/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.42 |
| ▸ | RELA | Q04206 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 8/20 | 0.42 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 6/20 | 0.41 |
| ▸ | CTSL | P07711 | 5/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2927699 | 0.89 | NPC1 (0.53) | CTSAPSMB5NFKB1NFKB2RELA | |
| SCHEMBL2931762 | 0.84 | CTSA (0.45) | CTSAPSMB5NFKB1NFKB2RELA | |
| SCHEMBL2931763 | 0.79 | CTSA (0.48) | CTSAPSMB5NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2931864 | 0.77 | KMT2A (0.57) | PSMB5NPC1RAB9ASMN1; SMN2PSMB8 | |
| SCHEMBL2927824 | 0.76 | NPC1 (0.48) | PSMB5NFKB1NFKB2RELANPC1 | |
| SCHEMBL2935265 | 0.76 | NPC1 (0.56) | CTSAPSMB5NFKB1NFKB2RELA | |
| SCHEMBL2927696 | 0.74 | CTSA (0.44) | CTSAPSMB5NFKB1NFKB2RELA | |
| SCHEMBL2931810 | 0.74 | NPC1 (0.45) | PSMB5NFKB1NFKB2RELANPC1 | |
| SCHEMBL2929343 | 0.73 | PSMB5 (0.55) | CTSAPSMB5NFKB1NFKB2RELA | |
| SCHEMBL2930834 | 0.72 | SMN1; SMN2 (0.48) | NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1846424-B1 | PROTEASOME INHIBITORS AND METHODS OF USING THE SAME | CEPHALON INC (US) | 2010-01-27 | — | — | EP | claimed |