Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | XBP1 | P17861 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3727112 | 0.91 | IGF1R (0.54) | IGF1RNPC1RAB9AMAPTPKM | |
| SCHEMBL2999377 | 0.89 | MAPT (0.43) | IGF1RNPC1RAB9AMAPTPKM | |
| SCHEMBL2940910 | 0.86 | IGF1R (0.51) | IGF1RNPC1RAB9AMAPTPKM | |
| SCHEMBL2938398 | 0.82 | IGF1R (0.53) | IGF1RNPC1RAB9A | |
| SCHEMBL2939261 | 0.82 | ACKR3 (0.44) | IGF1RNPC1RAB9AMAPTPKM | |
| SCHEMBL2942815 | 0.82 | IGF1R (0.53) | IGF1RSMO | |
| SCHEMBL2939956 | 0.82 | SMO (0.47) | NPC1RAB9AMAPTPKMSMN1; SMN2 | |
| SCHEMBL2940716 | 0.81 | IGF1R (0.54) | IGF1RSMO | |
| SCHEMBL3732841 | 0.81 | SMO (0.46) | IGF1RNPC1RAB9APKMTP53 | |
| SCHEMBL2941236 | 0.77 | IGF1R (0.53) | IGF1RNPC1RAB9AMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-B1 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA SA (FR) | 2010-09-22 | — | — | EP | disclosed |