Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | TBK1 | Q9UHD2 | 7/20 | 0.33 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.32 |
| ▸ | PTGES | O14684 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2935297 | 0.91 | KCNH2 (0.35) | KCNH2HRH4PIK3CDPIK3CBMTOR | |
| SCHEMBL2926403 | 0.90 | PIK3CA (0.41) | PIK3CDPIK3CBMTORTBK1 | |
| SCHEMBL2931516 | 0.90 | KCNH2 (0.39) | KCNH2HRH4PIK3CDPIK3CBMTOR | |
| SCHEMBL2924534 | 0.88 | KCNH2 (0.35) | KCNH2HRH4PIK3CDPIK3CBMTOR | |
| SCHEMBL2925852 | 0.86 | DRD3 (0.37) | KCNH2HRH4PIK3CDPIK3CBMTOR | |
| SCHEMBL2923944 | 0.84 | KCNH2 (0.35) | KCNH2HRH4PIK3CDPIK3CBMTOR | |
| SCHEMBL2931207 | 0.84 | KCNH2 (0.35) | KCNH2HRH4PIK3CDPIK3CBMTOR | |
| SCHEMBL2927890 | 0.84 | KCNH2 (0.35) | KCNH2HRH4PIK3CDPIK3CBMTOR | |
| SCHEMBL2933096 | 0.83 | KCNH2 (0.35) | KCNH2HRH4PIK3CDPIK3CBMTOR | |
| SCHEMBL2926127 | 0.83 | KCNH2 (0.35) | KCNH2HRH4PIK3CDPIK3CBMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8377983-B2 | Benzazole derivatives, compositions, and methods of use as aurora kinase inhibitors | TRANSTECH PHARMA, INC. (US) | 2013-02-19 | — | — | US | disclosed |
| US-7820821-B2 | Benzazole derivatives, compositions, and methods of use as aurora kinase inhibitors | TRANSTECH PHARMA, INC. (US) | 2010-10-26 | — | — | US | disclosed |
| US-20100152170-A1 | Benzazole Derivatives, Compositions, And Methods Of Use As Aurora Kinase Inhibitors | TRANSTECH PHARMA, INC. (US) | 2010-06-17 | — | — | US | disclosed |
| US-20070219235-A1 | Benzazole derivatives, compositions, and methods of use as aurora kinase inhibitors | VTVX HOLDINGS I LLC | 2007-09-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100152170-A1 | Benzazole Derivatives, Compositions, And Methods Of Use As Aurora Kinase Inhibitors | AURKC, AURKA, AURKB | KCNH2 1911/4885HRH4 2428/4885PIK3CD 59/4885 |
| US-20070219235-A1 | Benzazole derivatives, compositions, and methods of use as aurora kinase inhibitors | AURKC, AURKA, AURKB | KCNH2 1911/4885HRH4 2428/4885PIK3CD 59/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.