Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 3/20 | 0.49 |
| ▸ | GSK3B | P49841 | 2/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.49 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.49 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.49 |
| ▸ | CSNK1G2 | P78368 | 2/20 | 0.49 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.49 |
| ▸ | MINK1 | Q8N4C8 | 2/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.49 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.49 |
| ▸ | PRKCG | P05129 | 1/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.49 |
| ▸ | FLT4 | P35916 | 1/20 | 0.49 |
| ▸ | FRK | P42685 | 1/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.49 |
| ▸ | GSK3A | P49840 | 1/20 | 0.49 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.49 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2929634 | 0.85 | MAPK13 (0.46) | MAP4K4GSK3BPRKD3MAPK1MAPK9 | |
| SCHEMBL1387050 | 0.84 | MAP4K4 (0.46) | MAP4K4GSK3BPRKD3MAPK1MAPK9 | |
| SCHEMBL4408259 | 0.84 | MAP4K4 (0.50) | MAP4K4GSK3BPRKD3MAPK1MAPK9 | |
| SCHEMBL4412103 | 0.83 | MAP4K4 (0.49) | MAP4K4GSK3BPRKD3MAPK1MAPK9 | |
| SCHEMBL2926186 | 0.79 | DYRK1A (0.39) | GSK3BGSK3AMAPK14DYRK1AKCNH2 | |
| SCHEMBL4415343 | 0.78 | PRKD3 (0.49) | MAP4K4GSK3BPRKD3MAPK1MAPK9 | |
| SCHEMBL1385209 | 0.77 | MAPK14 (0.49) | CSNK1DMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL2929968 | 0.77 | MAPK13 (0.52) | MAP4K4GSK3BPRKD3MAPK1MAPK9 | |
| SCHEMBL2929971 | 0.77 | MAPK13 (0.52) | MAP4K4GSK3BPRKD3MAPK1MAPK9 | |
| SCHEMBL2927860 | 0.76 | CSNK1D (0.54) | MAP4K4GSK3BPRKD3MAPK1MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8536194-B2 | Pyrazolopyridine derivates | PALAU PHARMA, S.A. (ES) | 2013-09-17 | — | — | US | claimed |
| EP-1611131-B1 | PYRAZOLOPYRIDINE DERIVATES | PALAU PHARMA SA (ES) | 2010-09-15 | — | — | EP | claimed |
| US-20090005377-A1 | Pyrazolopyridine Derivates | PALAU PHARMA, S.A. (ES) | 2009-01-01 | — | — | US | claimed |
| US-7468376-B2 | Pyrazolopyridine derivates | PALAU PHARMA, S.A. (ES) | 2008-12-23 | — | — | US | claimed |
| US-20060167040-A1 | Pyrazolopyridine derivates | J. URIACH Y COMPANIA S.A. (ES) | 2006-07-27 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060167040-A1 | Pyrazolopyridine derivates | MAPK1, MAP4K2, MAP4K3 | MAP4K4 24/4885GSK3B 1601/4885PRKD3 221/4885 |
| US-20090005377-A1 | Pyrazolopyridine Derivates | MAPK1, MAPK4, MAP4K2 | MAP4K4 32/4885GSK3B 1958/4885PRKD3 126/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.