Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 13/20 | 0.45 |
| ▸ | MAPK3 | P27361 | 7/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 7/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29321580 | 1.00 | KRAS (0.45) | KRASMAPK3MAPK1 | |
| SCHEMBL30873378 | 1.00 | KRAS (0.45) | KRASMAPK3MAPK1 | |
| SCHEMBL29333528 | 0.97 | KRAS (0.44) | KRASMAPK3MAPK1 | |
| SCHEMBL30873369 | 0.95 | KRAS (0.44) | KRASMAPK3MAPK1 | |
| SCHEMBL29322585 | 0.95 | KRAS (0.44) | KRASMAPK3MAPK1 | |
| SCHEMBL29321700 | 0.95 | KRAS (0.44) | KRASMAPK3MAPK1 | |
| SCHEMBL29321648 | 0.93 | KRAS (0.46) | KRASMAPK3MAPK1 | |
| SCHEMBL30978069 | 0.93 | KRAS (0.46) | KRASMAPK3MAPK1 | |
| SCHEMBL29323624 | 0.92 | KRAS (0.47) | KRASMAPK3MAPK1 | |
| SCHEMBL29321588 | 0.92 | KRAS (0.47) | KRASMAPK3MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240228512-A1 | ACYCLIC OXAZEPINE COMPOUNDS COMPRISING A 6-AZA MOIETY AND USES THEREOF | GENENTECH, INC. (US) | 2024-07-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240228512-A1 | ACYCLIC OXAZEPINE COMPOUNDS COMPRISING A 6-AZA MOIETY AND USES THEREOF | AZI2, HDAC5, HDAC4 | KRAS 1190/4885MAPK3 3866/4885MAPK1 4628/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.