Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 20/20 | 0.89 |
| ▸ | PRKCD | Q05655 | 20/20 | 0.89 |
| ▸ | PRKCH | P24723 | 2/20 | 0.69 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.69 |
| ▸ | PRKCB | P05771 | 1/20 | 0.56 |
| ▸ | FYN | P06241 | 1/20 | 0.56 |
| ▸ | LYN | P07948 | 1/20 | 0.56 |
| ▸ | HCK | P08631 | 1/20 | 0.56 |
| ▸ | SRC | P12931 | 1/20 | 0.56 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.56 |
| ▸ | CDK2 | P24941 | 1/20 | 0.56 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.56 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2936541 | 0.99 | PRKCQ (0.88) | PRKCQPRKCDPRKCHPRKCEPRKCB | |
| SCHEMBL2936542 | 0.99 | PRKCQ (0.88) | PRKCQPRKCDPRKCHPRKCEPRKCB | |
| SCHEMBL2932987 | 0.94 | PRKCQ (1.00) | PRKCQPRKCDPRKCHPRKCEPRKCB | |
| SCHEMBL2936462 | 0.91 | PRKCQ (0.89) | PRKCQPRKCDPRKCHPRKCE | |
| SCHEMBL2935964 | 0.90 | PRKCQ (0.89) | PRKCQPRKCDPRKCHPRKCEPRKCB | |
| SCHEMBL2935968 | 0.90 | PRKCQ (0.89) | PRKCQPRKCDPRKCHPRKCEPRKCB | |
| SCHEMBL2932268 | 0.89 | PRKCQ (0.88) | PRKCQPRKCDPRKCHPRKCEPRKCB | |
| SCHEMBL2932269 | 0.89 | PRKCQ (0.88) | PRKCQPRKCDPRKCHPRKCEPRKCB | |
| SCHEMBL2935718 | 0.88 | PRKCQ (0.80) | PRKCQPRKCDPRKCHPRKCE | |
| SCHEMBL2935722 | 0.88 | PRKCQ (0.80) | PRKCQPRKCDPRKCHPRKCE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229377-A1 | 5-ALKYL/ALKENYL-3-CYANOPYRIDINES AS KINASE INHIBITORS | Wyeth LLC (US) | 2010-09-22 | — | — | EP | claimed |
| WO-2009076602-A1 | 5-ALKYL/ALKENYL-3-CYANOPYRIDINES AS KINASE INHIBITORS | WYETH (US) | 2009-06-18 | — | — | WO | claimed |