Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | NR2E3 | Q9Y5X4 | 7/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | MET | P08581 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | VCP | P55072 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | BAZ1A | Q9NRL2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29328000 | 0.83 | MAPT (0.49) | HDAC6NPC1RAB9AKMT2APPARG | |
| SCHEMBL29327715 | 0.82 | PPARG (0.47) | HDAC3HDAC1HDAC8HDAC6NR2E3 | |
| SCHEMBL29327844 | 0.82 | PPARG (0.60) | NPC1RAB9AKMT2APPARGMAPT | |
| SCHEMBL29327997 | 0.81 | HDAC6 (0.47) | HDAC6NPC1RAB9AKMT2APPARG | |
| SCHEMBL29327987 | 0.81 | PPARG (0.44) | NPC1RAB9AKMT2AKDRPPARG | |
| SCHEMBL29327992 | 0.81 | PPARG (0.44) | NPC1RAB9AKMT2AKDRPPARG | |
| SCHEMBL29327818 | 0.80 | PPARG (0.70) | NPC1RAB9APPARGMAPTTP53 | |
| SCHEMBL29327855 | 0.80 | PPARG (0.54) | NPC1RAB9APPARGMAPTTP53 | |
| SCHEMBL29327994 | 0.76 | PDE10A (0.42) | NPC1RAB9AKMT2APPARGTP53 | |
| SCHEMBL29327990 | 0.75 | PPARG (0.39) | NPC1RAB9AKMT2APPARGMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240239760-A1 | PPARG INVERSE AGONISTS AND USES THEREOF | FLARE THERAPEUTICS INC. | 2024-07-18 | — | — | US | disclosed |
| US-20240239760-A1 | PPARG INVERSE AGONISTS AND USES THEREOF | FLARE THERAPEUTICS INC. | 2024-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240239760-A1 | PPARG INVERSE AGONISTS AND USES THEREOF | PPARG, PPARA, PPARD | HDAC3 408/4885HDAC1 1077/4885HDAC8 893/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.