Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 1/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26743998 | 0.90 | CHRM5 (0.48) | CHRM5CHRM3HTTALDH1A1KDM4E | |
| SCHEMBL26743071 | 0.90 | CHRM5 (0.48) | CHRM5CHRM3HTTALDH1A1KDM4E | |
| SCHEMBL26743995 | 0.90 | CHRM5 (0.48) | CHRM5CHRM3HTTALDH1A1KDM4E | |
| SCHEMBL29328199 | 0.86 | CHRM5 (0.49) | CHRM5CHRM3HTTALDH1A1KDM4E | |
| SCHEMBL29324283 | 0.86 | CHRM5 (0.49) | CHRM5CHRM3HTTALDH1A1KDM4E | |
| SCHEMBL26741475 | 0.78 | CHRM5 (0.51) | CHRM5CHRM3HTTALDH1A1KDM4E | |
| SCHEMBL29328180 | 0.78 | HTT (0.45) | CHRM5CHRM3HTTALDH1A1KDM4E | |
| SCHEMBL29328274 | 0.77 | CHRM5 (0.43) | CHRM5CHRM3HTTALDH1A1KDM4E | |
| SCHEMBL26744518 | 0.76 | CHRM5 (0.50) | CHRM5CHRM3HTTALDH1A1KDM4E | |
| SCHEMBL26741494 | 0.76 | CHRM5 (0.50) | CHRM5CHRM3HTTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240238423-A9 | TETRAHYDROISOQUINOLINE HETEROBIFUNCTIONAL BCL-XL DEGRADERS | Treeline Biosciences, Inc. | 2024-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240238423-A9 | TETRAHYDROISOQUINOLINE HETEROBIFUNCTIONAL BCL-XL DEGRADERS | BCL2A1, BCL2L1, BCL3 | CHRM5 4872/4885CHRM3 4860/4885HTT 889/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.