Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | THPO | P40225 | 1/20 | 0.34 |
| ▸ | GMNN | O75496 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18822214 | 0.80 | — | — | |
| SCHEMBL19356014 | 0.78 | — | — | |
| SCHEMBL5163982 | 0.78 | — | — | |
| SCHEMBL22811900 | 0.77 | SLC6A2 (0.39) | TSHRCYP2D6NFKB1SLC6A2SLC6A4 | |
| SCHEMBL21914945 | 0.77 | TSHR (0.35) | TSHRCYP2D6NFKB1SLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL8152072 | 0.75 | — | — | |
| Hydrochloric Acid SCHEMBL8152067 | 0.75 | — | — | |
| SCHEMBL11056121 | 0.75 | — | — | |
| SCHEMBL14875499 | 0.74 | TSHR (0.41) | TSHRCYP2D6NFKB1ALDH1A1MAPK1 | |
| SCHEMBL20245850 | 0.72 | TSHR (0.53) | TSHRCYP2D6NFKB1ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024151772-A2 | POLYNUCLEIC ACID MOLECULES FOR INHIBITING EXPRESSION OF ANGPTL3, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | SIRIUS THERAPEUTICS, INC. (US) | 2024-07-18 | — | — | WO | disclosed |