SCHEMBL29333301

SCHEMBL29333301

CC(C)n1c(=O)c(OCC(=O)N(C)C)cc2cc(Nc3nc(N4CCC(I)CC4)ncc3Cl)ccc21

nearest known ligand 0.52

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ BCL6 P41182 20/20 0.52
▸ MELK Q14680 1/20 0.52
▸ NCOR2 Q9Y618 4/20 0.52
▸ CHRM4 P08173 1/20 0.50
▸ BCL6B Q8N143 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24717374 0.94 BCL6 (0.56) BCL6MELKNCOR2CHRM4BCL6B
SCHEMBL23267138 0.91 BCL6 (0.63) BCL6MELKNCOR2CHRM4BCL6B
SCHEMBL24717343 0.91 BCL6 (0.53) BCL6MELKNCOR2CHRM4BCL6B
SCHEMBL23267121 0.91 BCL6 (0.64) BCL6MELKNCOR2CHRM4BCL6B
SCHEMBL29333302 0.90 BCL6 (0.54) BCL6MELKNCOR2CHRM4BCL6B
SCHEMBL24718728 0.89 BCL6 (0.56) BCL6MELKNCOR2CHRM4BCL6B
SCHEMBL24717612 0.86 BCL6 (0.52) BCL6MELKNCOR2CHRM4BCL6B
SCHEMBL20284408 0.86 BCL6 (0.68) BCL6MELKNCOR2CHRM4BCL6B
SCHEMBL24718727 0.85 BCL6 (0.58) BCL6MELKNCOR2CHRM4BCL6B
SCHEMBL29335087 0.85 BCL6 (0.61) BCL6MELKNCOR2CHRM4BCL6B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024151557-A1 MODULATORS OF BCL6 PROTEOLYSIS AND ASSOCIATED METHODS OF USE ARVINAS OPERATIONS, INC. (US) 2024-07-18 — — WO disclosed
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