Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 20/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 13/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 13/20 | 0.50 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.44 |
| ▸ | TACR1 | P25103 | 2/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.44 |
| ▸ | HRH1 | P35367 | 2/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2933533 | 1.00 | CHRM3 (0.50) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| Bromide SCHEMBL2795432 | 0.99 | CHRM3 (0.51) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| Bromide SCHEMBL2795430 | 0.99 | CHRM3 (0.51) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL2929814 | 0.94 | CHRM3 (0.51) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| Bromide SCHEMBL2799405 | 0.93 | CHRM3 (0.52) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| Bromide SCHEMBL2799401 | 0.93 | CHRM3 (0.52) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL2932252 | 0.91 | CHRM3 (0.52) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| Bromide SCHEMBL2792550 | 0.90 | CHRM3 (0.52) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| Bromide SCHEMBL2792547 | 0.90 | CHRM3 (0.52) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL2933555 | 0.90 | CHRM3 (0.51) | CHRM3CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1811999-B1 | QUINUCLIDINE DERIVATIVES AND THEIR USE AS MUSCARINIC M3 RECEPTOR ANTAGONISTS | NOVARTIS AG (CH) | 2010-09-15 | — | — | EP | claimed |