Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 18/20 | 0.59 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.58 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.58 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.58 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.58 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.58 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.54 |
| ▸ | PSMB1 | P20618 | 3/20 | 0.53 |
| ▸ | PSMB11 | A5LHX3 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2927497 | 0.91 | PSMB5 (0.58) | PSMB5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2931289 | 0.90 | PSMB5 (0.58) | PSMB5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2934011 | 0.89 | PSMB5 (0.59) | PSMB5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL13079048 | 0.89 | PSMB5 (0.64) | PSMB5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2927498 | 0.88 | PSMB5 (0.56) | PSMB5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2931822 | 0.88 | PSMB5 (0.58) | PSMB5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2933171 | 0.88 | PSEN1 (0.58) | PSMB5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2932867 | 0.88 | PSMB5 (0.58) | PSMB5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2929773 | 0.87 | PSMB5 (0.56) | PSMB5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2935034 | 0.86 | PSMB5 (0.59) | PSMB5PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1846424-B1 | PROTEASOME INHIBITORS AND METHODS OF USING THE SAME | CEPHALON INC (US) | 2010-01-27 | — | — | EP | claimed |