Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.47 |
| ▸ | MTOR | P42345 | 2/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 2/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15187773 | 0.89 | PIK3CA (0.47) | PIK3CAMTORESR2NR1H2GPR119 | |
| SCHEMBL21461289 | 0.86 | ESR2 (0.53) | PIK3CAMTORESR2NR1H2GPR119 | |
| SCHEMBL2145067 | 0.85 | NR1H2 (0.54) | PIK3CAMTORESR2NR1H2GPR119 | |
| SCHEMBL17141692 | 0.85 | PIK3CA (0.46) | PIK3CAMTORESR2NR1H2HDAC1 | |
| SCHEMBL18863339 | 0.85 | PIK3CA (0.46) | PIK3CAMTORESR2NR1H2ACHE | |
| SCHEMBL30884565 | 0.84 | PIK3CA (0.46) | PIK3CAMTORESR2ACHEHTR2A | |
| SCHEMBL30681394 | 0.83 | PIK3CA (0.45) | PIK3CAMTORESR2NR1H2GPR119 | |
| SCHEMBL20184050 | 0.82 | PIK3CA (0.44) | PIK3CAMTORESR2NR1H2GPR119 | |
| SCHEMBL23771943 | 0.81 | KDM4E (0.51) | PIK3CAMTORLMNAHDAC1CYP3A4 | |
| SCHEMBL29814717 | 0.81 | KDM4E (0.51) | PIK3CAMTORLMNAHDAC1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3365334-B1 | BENZOLACTAM COMPOUNDS AS PROTEIN KINASE INHIBITORS | OTSUKA PHARMA CO LTD (JP) | 2024-07-17 | — | — | EP | disclosed |