Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 14/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 4/20 | 0.39 |
| ▸ | PLAU | P00749 | 4/20 | 0.39 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21244228 | 0.90 | ELANE (0.60) | ELANEL3MBTL1NR4A2F2PLAU | |
| SCHEMBL29121871 | 0.85 | ELANE (0.56) | ELANEL3MBTL1NR4A2F2PLAU | |
| SCHEMBL29121872 | 0.85 | ELANE (0.56) | ELANEL3MBTL1NR4A2F2PLAU | |
| SCHEMBL30676466 | 0.85 | ELANE (0.56) | ELANEL3MBTL1NR4A2F2PLAU | |
| SCHEMBL30676560 | 0.85 | ELANE (0.56) | ELANEL3MBTL1NR4A2F2PLAU | |
| SCHEMBL29122225 | 0.85 | ELANE (0.56) | ELANEL3MBTL1NR4A2F2PLAU | |
| SCHEMBL17419175 | 0.80 | ELANE (0.64) | ELANEL3MBTL1NR4A2F2PLAU | |
| SCHEMBL31646748 | 0.80 | ELANE (0.64) | ELANEL3MBTL1NR4A2F2PLAU | |
| SCHEMBL498197 | 0.79 | ELANE (0.51) | ELANEL3MBTL1NR4A2F2PLAU | |
| SCHEMBL29121991 | 0.79 | ELANE (0.57) | ELANEL3MBTL1NR4A2F2PLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240239752-A1 | BICYCLIC HETEROAROMATIC INHIBITORS OF KLK5 | WILMINGTON TRUST, NATIONAL ASSOCIATION | 2024-07-18 | — | — | US | disclosed |
| US-20240239752-A1 | BICYCLIC HETEROAROMATIC INHIBITORS OF KLK5 | WILMINGTON TRUST, NATIONAL ASSOCIATION | 2024-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240239752-A1 | BICYCLIC HETEROAROMATIC INHIBITORS OF KLK5 | KLK5, KLK1, KLKB1 | ELANE 110/4885L3MBTL1 3540/4885NR4A2 2887/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.