Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2934107 | 1.00 | MAPK1 (0.47) | MAPK1POLBL3MBTL1SMN1; SMN2HPGD | |
| SCHEMBL1504207 | 0.82 | MAPK1 (0.52) | MAPK1POLBL3MBTL1SMN1; SMN2HPGD | |
| SCHEMBL1504202 | 0.82 | MAPK1 (0.52) | MAPK1POLBL3MBTL1SMN1; SMN2HPGD | |
| SCHEMBL12035790 | 0.82 | MAPK1 (0.54) | MAPK1POLBL3MBTL1SMN1; SMN2HPGD | |
| SCHEMBL6362939 | 0.80 | F10 (0.36) | MAPTMEN1KMT2ANPC1LMNA | |
| SCHEMBL4268500 | 0.79 | MAPK1 (0.47) | MAPK1POLBL3MBTL1SMN1; SMN2MAPT | |
| SCHEMBL4268490 | 0.79 | MAPK1 (0.47) | MAPK1POLBL3MBTL1SMN1; SMN2MAPT | |
| SCHEMBL6361764 | 0.78 | F10 (0.32) | — | |
| SCHEMBL6362834 | 0.77 | TSHR (0.33) | SMN1; SMN2MAPTRECQLMEN1KMT2A | |
| SCHEMBL2940481 | 0.77 | F10 (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100093785-A1 | DIAMINE DERIVATIVES | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2010-04-15 | — | — | US | disclosed |
| US-20050119486-A1 | Diamine derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2005-06-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100093785-A1 | DIAMINE DERIVATIVES | C9, C1S, C1R | MAPK1 1701/4885POLB 1264/4885L3MBTL1 309/4885 |
| US-20050119486-A1 | Diamine derivatives | C9, C1S, C1R | MAPK1 1864/4885POLB 868/4885L3MBTL1 385/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.