Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | TYMP | P19971 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 4/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | GBA1 | P04062 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PNP | P00491 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26691334 | 0.87 | — | — | |
| SCHEMBL25147628 | 0.83 | CYP2D6 (0.50) | CYP2D6MAPTHTTLTA4HCYP3A4 | |
| SCHEMBL3431958 | 0.80 | CYP2D6 (0.45) | CYP2D6MAPTHTTLTA4HCYP3A4 | |
| SCHEMBL3897612 | 0.80 | CYP2D6 (0.45) | CYP2D6MAPTHTTLTA4HCYP3A4 | |
| SCHEMBL10064309 | 0.80 | CYP2D6 (0.45) | CYP2D6MAPTHTTLTA4HCYP3A4 | |
| SCHEMBL772309 | 0.79 | CYP2D6 (0.47) | CYP2D6MAPTHTTLTA4HCYP3A4 | |
| SCHEMBL1283526 | 0.79 | CYP2D6 (0.47) | CYP2D6MAPTHTTLTA4HCYP3A4 | |
| SCHEMBL645562 | 0.79 | CYP2D6 (0.47) | CYP2D6MAPTHTTLTA4HCYP3A4 | |
| SCHEMBL3431959 | 0.79 | CYP2D6 (0.47) | CYP2D6MAPTHTTLTA4HCYP3A4 | |
| SCHEMBL1283776 | 0.79 | CYP2D6 (0.47) | CYP2D6MAPTHTTLTA4HCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229362-A1 | PIPERAZINES AS ANTI-OBESITY AGENTS | AstraZeneca AB (SE) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009071658-A1 | PIPERAZINES AS ANTI-OBESITY AGENTS | BIOVITRUM AB (PUBL) (SE) | 2009-06-11 | — | — | WO | disclosed |