Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 6/20 | 0.62 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.62 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.60 |
| ▸ | TYMS | P04818 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | FPR2 | P25090 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.40 |
| ▸ | MYLK | Q15746 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29936869 | 1.00 | CYP1A2 (0.62) | CYP1A2CYP2A6NR4A2TYMSKMT2A | |
| SCHEMBL11880529 | 0.84 | TSHR (0.41) | CYP1A2CYP2A6NR4A2CYP3A4TP53 | |
| SCHEMBL31238945 | 0.84 | TSHR (0.41) | CYP1A2CYP2A6NR4A2CYP3A4TP53 | |
| SCHEMBL4659232 | 0.84 | NR4A2 (0.64) | CYP1A2CYP2A6NR4A2TYMSKMT2A | |
| SCHEMBL10432943 | 0.84 | NR4A2 (0.64) | CYP1A2CYP2A6NR4A2TYMSKMT2A | |
| SCHEMBL25297003 | 0.80 | CYP1A2 (0.54) | CYP1A2CYP2A6NR4A2TYMSKMT2A | |
| SCHEMBL28883426 | 0.80 | CYP1A2 (0.54) | CYP1A2CYP2A6NR4A2TYMSCHEK1 | |
| SCHEMBL31178732 | 0.80 | CYP1A2 (0.54) | CYP1A2CYP2A6NR4A2TYMSKMT2A | |
| SCHEMBL2468811 | 0.79 | CYP1A2 (1.00) | CYP1A2CYP2A6NR4A2TYMSKMT2A | |
| SCHEMBL29629127 | 0.79 | CYP1A2 (1.00) | CYP1A2CYP2A6NR4A2TYMSKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240239788-A1 | SMALL MOLECULE INHIBITORS OF KRAS G12D MUTANT | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2024-07-18 | — | — | US | disclosed |
| US-20240239788-A1 | SMALL MOLECULE INHIBITORS OF KRAS G12D MUTANT | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2024-07-18 | — | — | US | disclosed |
| US-20240239788-A1 | SMALL MOLECULE INHIBITORS OF KRAS G12D MUTANT | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2024-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240239788-A1 | SMALL MOLECULE INHIBITORS OF KRAS G12D MUTANT | KRAS, NRAS, HRAS | CYP1A2 4576/4885CYP2A6 3523/4885NR4A2 4556/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.