Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 19/20 | 0.55 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.52 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.52 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.52 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.52 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.52 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.52 |
| ▸ | PSMB11 | A5LHX3 | 4/20 | 0.51 |
| ▸ | PSMA7 | O14818 | 4/20 | 0.51 |
| ▸ | PSMB1 | P20618 | 4/20 | 0.51 |
| ▸ | PSMA1 | P25786 | 4/20 | 0.51 |
| ▸ | PSMA2 | P25787 | 4/20 | 0.51 |
| ▸ | PSMA3 | P25788 | 4/20 | 0.51 |
| ▸ | PSMA4 | P25789 | 4/20 | 0.51 |
| ▸ | PSMB8 | P28062 | 4/20 | 0.51 |
| ▸ | PSMB9 | P28065 | 4/20 | 0.51 |
| ▸ | PSMA5 | P28066 | 4/20 | 0.51 |
| ▸ | PSMB4 | P28070 | 4/20 | 0.51 |
| ▸ | PSMB6 | P28072 | 4/20 | 0.51 |
| ▸ | PSMB10 | P40306 | 4/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13079063 | 0.89 | PSMB5 (0.58) | PSMB5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2934011 | 0.86 | PSMB5 (0.59) | PSMB5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2929419 | 0.85 | PSMB5 (0.57) | PSMB5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2931792 | 0.85 | PSMB5 (0.53) | PSMB5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2927498 | 0.83 | PSMB5 (0.56) | PSMB5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2929773 | 0.83 | PSMB5 (0.56) | PSMB5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2933384 | 0.82 | PSMB5 (0.59) | PSMB5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2935034 | 0.82 | PSMB5 (0.59) | PSMB5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2933171 | 0.82 | PSEN1 (0.58) | PSMB5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2931822 | 0.82 | PSMB5 (0.58) | PSMB5PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1846424-B1 | PROTEASOME INHIBITORS AND METHODS OF USING THE SAME | CEPHALON INC (US) | 2010-01-27 | — | — | EP | claimed |