Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 12/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 6/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2931732 | 0.87 | TTK (0.42) | TTKCCNA2CDK2LRRK2 | |
| SCHEMBL2930667 | 0.86 | TTK (0.41) | TTKCCNA2CDK2LRRK2DYRK1A | |
| Hydrochloric Acid SCHEMBL2930397 | 0.86 | TTK (0.42) | TTKCCNA2CDK2LRRK2 | |
| SCHEMBL14269675 | 0.86 | TTK (0.43) | TTKCCNA2CDK2LRRK2DYRK1A | |
| SCHEMBL13515303 | 0.85 | TTK (0.39) | TTKCCNA2CDK2LRRK2DYRK1A | |
| SCHEMBL2930971 | 0.84 | DYRK1A (0.47) | TTKCCNA2CDK2LRRK2DYRK1A | |
| Hydrochloric Acid SCHEMBL2936353 | 0.83 | MKNK1 (0.49) | TTKCCNA2CDK2LRRK2DYRK1A | |
| Trifluoroacetic Acid SCHEMBL2928635 | 0.83 | DYRK1A (0.47) | TTKLRRK2DYRK1A | |
| SCHEMBL2931716 | 0.83 | MKNK1 (0.42) | TTKCCNA2CDK2LRRK2 | |
| SCHEMBL2933015 | 0.83 | KDR (0.45) | TTKCCNA2CDK2LRRK2DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044051-B1 | PYRIDINE AND PYRAZINE DERIVATIVES AS MNK KINASE INHIBITORS | BIOVITRUM AB PUBL (SE) | 2010-01-27 | — | — | EP | claimed |