Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
| ▸ | HTR2B | P41595 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.34 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | MLNR | O43193 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12350598 | 0.84 | HCRTR1 (0.39) | TRPV1MAP4K1HCRTR1HCRTR2HSP90AA1 | |
| SCHEMBL1796112 | 0.83 | TRPV1 (0.44) | TRPV1HTR2AHTR2CHTR2BGAA | |
| SCHEMBL1801849 | 0.83 | HCRTR1 (0.38) | TRPV1CHRM1CHRM3GAAHSD17B3 | |
| SCHEMBL1801077 | 0.83 | TRPV1 (0.37) | TRPV1CHRM1CHRM3GAAHCRTR1 | |
| SCHEMBL1796478 | 0.82 | TRPV1 (0.40) | TRPV1MAP4K1 | |
| SCHEMBL1798617 | 0.81 | TRPV1 (0.41) | TRPV1CHRM1CHRM3 | |
| SCHEMBL1800931 | 0.79 | TRPV1 (0.47) | TRPV1HSD17B3 | |
| SCHEMBL1799943 | 0.77 | ALOX5AP (0.38) | TRPV1GAA | |
| SCHEMBL1796912 | 0.72 | CHRNA1 (0.39) | TRPV1GAAHCRTR1HCRTR2PDE10A | |
| SCHEMBL1797611 | 0.72 | TRPV1 (0.50) | TRPV1HCRTR1HCRTR2PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2021330-B1 | BENZIMIDAZOLE MODULATORS OF VR1 | JANSSEN PHARMACEUTICA NV (BE) | 2010-09-22 | — | — | EP | claimed |