SCHEMBL29347202

SCHEMBL29347202

Cn1c(=O)n(C2CCCC(=O)NC2=O)c2cccc(-c3ccncc3)c21

nearest known ligand 0.53

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ DDB1 Q16531 18/20 0.53
▸ CRBN Q96SW2 18/20 0.53
▸ MAP1LC3B Q9GZQ8 1/20 0.37
▸ ALDH1A1 P00352 1/20 0.37
▸ CHRM2 P08172 1/20 0.37
▸ OPRM1 P35372 1/20 0.37
▸ IKZF3 Q9UKT9 1/20 0.37
▸ CYP1A2 P05177 1/20 0.37
▸ TSHR P16473 1/20 0.37
▸ TDP1 Q9NUW8 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29347172 0.82 DDB1 (0.60) DDB1CRBNIKZF3
SCHEMBL21996668 0.78 DDB1 (0.58) DDB1CRBNALDH1A1CHRM2OPRM1
SCHEMBL29346395 0.78 CRBN (0.85) DDB1CRBNALDH1A1CHRM2OPRM1
SCHEMBL26102935 0.77 CRBN (0.54) DDB1CRBNALDH1A1CHRM2OPRM1
SCHEMBL26447957 0.76 DDB1 (0.58) DDB1CRBNALDH1A1CHRM2OPRM1
SCHEMBL29347177 0.75 DDB1 (0.52) DDB1CRBNIKZF3
SCHEMBL23602077 0.74 DDB1 (0.70) DDB1CRBNALDH1A1CHRM2OPRM1
SCHEMBL21759953 0.74 DDB1 (0.70) DDB1CRBNALDH1A1CHRM2OPRM1
SCHEMBL22525873 0.74 DDB1 (0.70) DDB1CRBNALDH1A1CHRM2OPRM1
SCHEMBL25568638 0.74 CRBN (0.70) DDB1CRBNALDH1A1CHRM2OPRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250388593-A1 CEREBLON E3 LIGASE BINDING COMPOUND, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND PRODUCTION METHOD THEREFOR MITSUBISHI TANABE PHARMA CORPORATION (JP) 2025-12-25 — — US disclosed
EP-4650348-A1 CEREBLON E3 LIGASE BINDING COMPOUND, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND PRODUCTION METHOD THEREFOR Mitsubishi Tanabe Pharma Corporation (JP) 2025-11-19 — — EP disclosed
WO-2024150815-A1 CEREBLON E3 LIGASE BINDING COMPOUND, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND PRODUCTION METHOD THEREFOR 田辺三菱製薬株式会社 2024-07-18 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250388593-A1 CEREBLON E3 LIGASE BINDING COMPOUND, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND PRODUCTION METHOD THEREFOR CRBN, CUL1, CBL DDB1 2368/4885CRBN 1/4885MAP1LC3B 3261/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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