Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 3/20 | 0.51 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | ESR1 | P03372 | 2/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.35 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.35 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.35 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1929738 | 0.89 | CHEK1 (0.65) | CHEK1METKDM4EKMT2A | |
| SCHEMBL2934974 | 0.86 | CHEK1 (0.54) | CHEK1METKDM4ESMN1; SMN2HRH3 | |
| SCHEMBL2935301 | 0.85 | CHEK1 (0.52) | CHEK1KDM4ESMN1; SMN2KMT2AHRH3 | |
| SCHEMBL2932598 | 0.85 | CHEK1 (0.52) | CHEK1KDM4ESMN1; SMN2KMT2AHRH3 | |
| SCHEMBL2932580 | 0.81 | CHEK1 (0.47) | CHEK1KDM4EKMT2AHRH3 | |
| SCHEMBL2933542 | 0.80 | CHEK1 (0.46) | CHEK1KMT2AHRH3 | |
| SCHEMBL1928162 | 0.75 | CHEK1 (0.69) | CHEK1METKDM4EKMT2A | |
| SCHEMBL1930902 | 0.74 | CHEK1 (0.67) | CHEK1KDM4EKMT2A | |
| SCHEMBL1927323 | 0.74 | CHEK1 (0.67) | CHEK1KDM4EKMT2A | |
| SCHEMBL1928564 | 0.70 | CHEK1 (0.61) | CHEK1KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421074-B1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2010-09-29 | — | — | EP | claimed |