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Sugi Predict / Compounds / SCHEMBL29348376

SCHEMBL29348376

SCHEMBL29348376

Cn1ccc(COc2ccc(-c3ccc(F)c(C4CCC(=O)NC4O)c3Cl)cc2)n1

nearest known ligand 0.39

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ JAK2 O60674 1/20 0.39
▸ GRM2 Q14416 1/20 0.37
▸ ALOX5AP P20292 15/20 0.35
▸ PDCD1 Q15116 1/20 0.35
▸ CD274 Q9NZQ7 1/20 0.35
▸ PDE10A Q9Y233 1/20 0.34
▸ HDAC1 Q13547 1/20 0.34
▸ HDAC6 Q9UBN7 1/20 0.34
▸ HDAC5 Q9UQL6 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29348771 0.85 JAK2 (0.44) JAK2GRM2ALOX5APPDCD1CD274
SCHEMBL29348770 0.85 JAK2 (0.44) JAK2GRM2ALOX5APPDCD1CD274
SCHEMBL29348717 0.84 CRBN (0.44) JAK2GRM2ALOX5APPDE10A
SCHEMBL31068187 0.84 CRBN (0.44) JAK2GRM2ALOX5APPDE10A
SCHEMBL29348725 0.78 JAK2 (0.41) JAK2ALOX5APPDCD1CD274
SCHEMBL31068277 0.77 CRBN (0.46) JAK2GRM2PDCD1CD274PDE10A
SCHEMBL29348378 0.76 JAK2 (0.40) JAK2GRM2ALOX5APPDE10AHDAC1
SCHEMBL29348377 0.74 CRBN (0.44) JAK2GRM2ALOX5APPDE10A
SCHEMBL31068149 0.72 CRBN (0.46) JAK2PDCD1CD274
SCHEMBL31068109 0.72 CRBN (0.46) JAK2PDCD1CD274

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024151547-A1 TARGETED DEGRADATION OF VAV1 MONTE ROSA THERAPEUTICS, INC. (US) 2024-07-18 — — WO disclosed