Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 13/20 | 0.46 |
| ▸ | DDB1 | Q16531 | 10/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31068377 | 1.00 | CRBN (0.46) | CRBNDDB1MAPK14PDCD1LG2CD274 | |
| SCHEMBL29348419 | 0.88 | DDB1 (0.42) | CRBNDDB1TP53MAPT | |
| SCHEMBL29348401 | 0.86 | CRBN (0.40) | CRBNDDB1IKZF3GRM2MCHR1 | |
| SCHEMBL29348758 | 0.84 | DDB1 (0.43) | CRBNDDB1IKZF3 | |
| SCHEMBL29348388 | 0.84 | DDB1 (0.43) | CRBNDDB1IKZF3 | |
| SCHEMBL31068322 | 0.84 | DDB1 (0.43) | CRBNDDB1IKZF3 | |
| SCHEMBL31068226 | 0.84 | DDB1 (0.43) | CRBNDDB1IKZF3 | |
| SCHEMBL29348430 | 0.84 | DDB1 (0.43) | CRBNDDB1IKZF3 | |
| SCHEMBL29348402 | 0.84 | CRBN (0.38) | CRBNDDB1MAPTIKZF3GRM2 | |
| SCHEMBL29348418 | 0.80 | CRBN (0.43) | CRBNDDB1IKZF3CXCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024151547-A1 | TARGETED DEGRADATION OF VAV1 | MONTE ROSA THERAPEUTICS, INC. (US) | 2024-07-18 | — | — | WO | disclosed |