Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 16/20 | 0.43 |
| ▸ | DDB1 | Q16531 | 15/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | JAK3 | P52333 | 2/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.34 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29348394 | 0.88 | DDB1 (0.43) | CRBNDDB1IKZF3 | |
| SCHEMBL29348602 | 0.86 | DDB1 (0.45) | CRBNDDB1IKZF3 | |
| SCHEMBL29348393 | 0.86 | CNR2 (0.42) | CRBNDDB1IKZF3 | |
| SCHEMBL29348552 | 0.85 | CRBN (0.42) | CRBNDDB1IKZF3 | |
| SCHEMBL29348285 | 0.85 | DDB1 (0.41) | CRBNDDB1IKZF3 | |
| SCHEMBL29348501 | 0.85 | CRBN (0.42) | CRBNDDB1IKZF3 | |
| SCHEMBL31068114 | 0.84 | DDB1 (0.41) | CRBNDDB1IKZF3 | |
| SCHEMBL29348852 | 0.84 | DDB1 (0.41) | CRBNDDB1IKZF3 | |
| SCHEMBL31068216 | 0.84 | CRBN (0.36) | CRBNDDB1IKZF3 | |
| SCHEMBL31068143 | 0.84 | CRBN (0.35) | CRBNDDB1IKZF3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024151547-A1 | TARGETED DEGRADATION OF VAV1 | MONTE ROSA THERAPEUTICS, INC. (US) | 2024-07-18 | — | — | WO | disclosed |