Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 9/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 8/20 | 0.39 |
| ▸ | CNR2 | P34972 | 3/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31068262 | 1.00 | CRBN (0.39) | CRBNDDB1CNR2HRH3L3MBTL1 | |
| SCHEMBL29348399 | 0.88 | HRH3 (0.45) | CRBNDDB1HRH3L3MBTL1IKZF3 | |
| SCHEMBL29348641 | 0.87 | DDB1 (0.41) | CRBNDDB1CNR2OPRK1 | |
| SCHEMBL31068165 | 0.87 | DDB1 (0.37) | CRBNDDB1CNR2PDK2 | |
| SCHEMBL29348640 | 0.87 | DDB1 (0.37) | CRBNDDB1CNR2PDK2 | |
| SCHEMBL31068183 | 0.87 | DDB1 (0.41) | CRBNDDB1CNR2OPRK1 | |
| SCHEMBL29348434 | 0.86 | HRH3 (0.42) | CRBNDDB1HRH3L3MBTL1IKZF3 | |
| SCHEMBL29348912 | 0.84 | DDB1 (0.38) | CRBNDDB1CNR2 | |
| SCHEMBL31068267 | 0.83 | CNR2 (0.59) | CRBNDDB1CNR2CNR1 | |
| SCHEMBL29348994 | 0.83 | CNR2 (0.59) | CRBNDDB1CNR2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024151547-A1 | TARGETED DEGRADATION OF VAV1 | MONTE ROSA THERAPEUTICS, INC. (US) | 2024-07-18 | — | — | WO | disclosed |