SCHEMBL29348644

SCHEMBL29348644

CN1CCCN(c2ccc(-c3cccc(C4CCC(=O)NC4=O)c3Cl)cn2)C1=O

nearest known ligand 0.47

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
CNR2 P34972 7/20 0.47
DDB1 Q16531 11/20 0.43
CRBN Q96SW2 11/20 0.43
CNR1 P21554 1/20 0.37
BRD4 O60885 2/20 0.37
CREBBP Q92793 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31068116 1.00 CNR2 (0.47) CNR2DDB1CRBNCNR1BRD4
SCHEMBL29348994 0.86 CNR2 (0.59) CNR2DDB1CRBNCNR1BRD4
SCHEMBL31068267 0.86 CNR2 (0.59) CNR2DDB1CRBNCNR1BRD4
SCHEMBL29348472 0.86 CRBN (0.43) DDB1CRBNBRD4CREBBP
SCHEMBL31068225 0.85 DDB1 (0.40) CNR2DDB1CRBN
SCHEMBL29348597 0.85 DDB1 (0.40) CNR2DDB1CRBN
SCHEMBL29348996 0.84 CNR2 (0.47) CNR2DDB1CRBNCNR1BRD4
SCHEMBL31068290 0.84 CNR2 (0.47) CNR2DDB1CRBNCNR1BRD4
SCHEMBL31068183 0.84 DDB1 (0.41) CNR2DDB1CRBN
SCHEMBL29348641 0.84 DDB1 (0.41) CNR2DDB1CRBN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024151547-A1 TARGETED DEGRADATION OF VAV1 MONTE ROSA THERAPEUTICS, INC. (US) 2024-07-18 WO disclosed